I've done this commute (But M-Th) since 2017, with the exception of 2 years of covid-induced WFH. (Prior to that I did the daily shuttle commute from SF 2008-2017) Alaska is my go-to. Prior to everyone doing away with change fees, WN was my backup carrier. Now DL is my backup and gets maybe 10% of it.

It's totally doable, but be careful that you don't get tired. I've found I have to listen to my body more carefully than I did before. Some early weeks where I would have "forced" myself to "just go to work like a normal person" would have been fine in the past (in my 20's, on a daily commute) but had become a mistake that led to crankiness and needing to apologize both at home and to a coworker. After figuring that out, talking to my manager usually resulted in him telling me to stay home that week. I have a cool manager in this regard, who was totally on-board with my commute. Hopefully yours is, too. If we have the same employer, they're offering you 4 weeks a year fully remote, I recommend you use those to make sure you get home weeks every once in a while.

I echo [MENTION=288658]TravelingChef[/MENTION], that for me the most surprisingly-painful part was travel to/from SJC. I used to Lyft to/from, but found my patience for it grew thinner and thinner and now I usually rent cars.​ In the early days, I'd sometimes take the company shuttle to Santa Clara Caltrain, and then VTA 10 around the runways to the terminal. It was a total pain and is never my Plan A now. (For context, I love Link Light Rail, and regularly take it to/from SEA, so I'm not at all opposed to transit in general.)

Another option in not-plan-A territory if you need to SDC to SFO, is to take the shuttle to the Colma P&R, and then BART to SFO.

Great advice from [MENTION=3309]lalala[/MENTION]! Absolutely ask around with coworkers if you can rent a room as a crash pad. That's what I did, and I was able to get one within walking distance of the intercampus shuttle for $500/mo. I don't ever have guests over, I always shower and eat at work so I add almost nothing to the utilities, and my coworker can still use the room as a guest room on weekends if they need to.

If your campus is a big tech HQ like mine, and you want to be within a few minutes walking (or even driving), don't expect hotels to be "a few hundred every month". Expect several hundred per night. "Absurd" is absolutely the correct word. The Residence Inn two blocks from my office is regularly ~$150 on weekends and is now regularly back into >$500 per night on Mon-Wed. They know the company is paying for it (for others, not you and me) and can afford to put up people close by. Interestingly, in the past, I've found it to be a fabulous use of Marriott 35k certificates for nights where I've wanted some peace and privacy.

One area where we may be totally different and my advice might not be at all relevant is travel time of day. I'm not a morning person, and getting up early on Monday to catch a flight was really brutal for me. Even though it was an extra night away, I found my quality of life improved a ton when I started always flying in the evening. It also made irrops much easier to handle, and I haven't missed a meeting or rolled in late due to an airline since that change. You can always look around, take the temp of the office, and see if you can SDC and leave early, but if a 9am disaster strikes and you're over Yreka, it's really obvious to others.

Other than that, I'd mostly agree with everything everyone else has said upthread. All good advice here.