With all due respect, aisle seat(s) can never be the “best”, too many knapsacks and carry-ons banging heads and shoulders during boarding, too many bellys smacking shoulders while people access the overhead, too many beverage carts running over toes and banging elbows, too much worry about something being spilled from the beverage cart, too many times getting up and down for the middle and window seat pax(s) who forgot to wear Depends.

Window seat, emergency exit row (more aft of 2 emergency exit rows if applicable), side of plane opposite the sun. Tons of leg room, seat in front cannot recline, (theoretically) no POS (person of size) seatmates, no sun glare through window, no window shade greenhouse heating if window shade pulled down, and in a very rare emergency egress first person out of the plane. Only downside is occasionally it’s a very cold seat, particularly on longer flights.

(Studies are inconclusive on the “safest” part of an airplane; some conclude the front, some conclude the back, some the middle, but all studies agree that survival probability is dependent on being able to get out of the plane YOURSELF, few survivors are carried out by others. And in the event of an emergency egress one would obviously want to be among the first people out; toxic fumes from melting plastic, fire, and smoke are all more problematic with greater exposure time.)

Only 1 truism for aircraft emergencies, the pilot(s) is always the first to arrive .