Update:
45 days after they zeroed out the inventory and two months prior to takeoff, they finally notified us of the flight cancellation. They moved us onto the later flight PTY-SFO but kept us on our original (early) departure from MDE, leaving us with nearly 8 hours in Panama City.

The later MDE-PTY flight is fully open in business when trying to purchase the single leg (no seats even taken), but they have zeroed out the inventory if you want to route MDE-SFO for some reason. This flight would give us a valid, 45-minute connection and was available for sale just yesterday.

Calling this morning to try and make sense of this and get them to move us to the later flight. Not wanting to spend 8 hours in PTY.