Whether you can or not is very different from whether or not you should.

Most airlines do not permit voice calls inflight, even if it’s possible. I’m guilty of having done it a few times though WiFi calling and FaceTime, but only very briefly and I always made sure my voice was never at a level where anyone else could hear. In J and F it’s definitely possible to speak and have no one ever hear you.

I would never do this for a work call though. I would sound like a combination of Barry White and Batman to the people on the other end. Not overly professional.