I'm a Row 2 Aisle kind of guy. I'm too tall for the bulkhead seats, but will take it if that's all there is... and I usually have to use the lav more than once so prefer the Aisle to make that easy.
Last row is an absolute last resort. I have had kids kicking seats, people pulling on them constantly, and on one flight, a lady behind me put her nasty ... bare feet on the center arm rest like it was an ottoman.
If I am on an E75, Give me 2A or 3A.