I've flown the A350 with children - but somewhat older than yours are. But I have a parent's eye... and I'd say you face a bit of a challenge. The A350s are lovely for grown-ups in Club - so much more space, etc etc. But that's precisely the reason why you will find the space challenging with a two-year old, and reaching over will be something of a challenge.
And while it is true that there's no guarantee of what plane will be on what route in the coming months, the A350 seems to have been a pandemic favorite for BA to use, covering quite a few routes where it wouldn't normally be seen. So it's certainly popular in the current climate. Do you have a specific route in mind?