The solution that skywalkerLAX mentions is extremely common in many hotels. Back when I worked at a Front Desk, preparing a split bill that separated specific charges under different names was something we did maybe once per week.
Essentially, it's a variation on the concept of splitting a bill for one guest into reimbursable charges (room/tax) and personal charges (things like alcohol). That's something that happened almost daily during the business week where I worked.
Any reasonably competent Front Desk clerk should be able to handle this task. But, it's probably worth highlighting the fact that some employers might not accept these folios for reimbursement purposes.