FlyerTalk Forums - View Single Post - AstraZeneca [and other] vaccine trial experience

Nov 24, 2020, 7:09 am

#7

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Quote:

Originally Posted by nk15

Every vaccine trial should have been doing that, this is critical. I mean what's the point otherwise, a job half done...

Moderna's chief medical officer says that vaccine trial results only show that they prevent people from getting severely sick — not necessarily that recipients won't still be able to transmit the virus

I agree. I believe this sub-study is where AZ made the inference of some sterilizing immunity in their press release.

Additionally, there was a fascenating discussion on TWiV last week on the persistance of immunity where they discussed this pre-print. Immunological memory to SARS-CoV-2 assessed for greater than six months after infection

This very discussion was brought up and the virologist from that paper has some ideas as to whether the Moderna and/or Pfizer would provide steralizing immunity based on the immune responses they trigger - he seemed to think they would but couldn't say for sure. In any case, it seems logistically it would be hard to mandate weekly Covid testing for participants though that wouldn't be an insurmountable challenge.

TWiV 684: Persistence of SARS-CoV-2 immune memory (discussion starts at 47 minutes and goes for about an hour).