I would notify Amex Fraud. The #1 issue is to cancel the card and get it replaced, Be prepared to supply a copy of the note from Amazon. Amex will almost certainly ask which charges were fraudulent and that will likely lead to a credit for those.

As this is the second time for you and with a different card, you should carefully consider who might have access to your accounts and where you do business. Change all passwords on all accounts and make certain that they are all different. The source of the fraud could be almost anywhere, but you might focus on merchants which do not have conactless "touch" or who are not using chip readers (where you insert the card).

I would also enable the text notification feature on your card and set it to $0, so that you receive a text every time there is activity on the account.

Once it is all settled, go back to Amazon to open a new account with the new card. At that point, I would also set up OTP so that you receive a one-time passcode every time you log in. Don't forget that if you share your laptop or other device with others or others may have access to it and you also store passwords on your device that you are essentially leaving the account open and unlocked.. A bit of a hassle, but the convenience is not made up for by this hassle.