No, you need to get a "digital key" as well as check in, in order to skip the front desk. Not all hotels offer a digital key even if they allow you to check in and choose your room. If you do get a digital key then you may not need to interact with any staff at all during your stay...

In some countries you need to present ID, so you have to go to the front desk.

Some hotels want you to present a voucher to get your free breakfast which you may need to collect at the front desk. Also if they give drink coupons.