Well, your basic question is a bit hard to answer to answer right now, because we don't know for sure what airlines are going to change their flight schedule and the planes they fly by 2022. Some airlines which currently have international first class might get rid of it by then if no business purchases of seats in that came come back by then.

Meanwhile, you should study up on the airlines that your current programs transfer into (especially the ones that multiple programs you have points in share), because you may or may not already have enough points/miles already, but different programs require different amounts of miles for the same flights (though that can change over time, too), so some foreign airline that is neither based where are flying from or where are flying too might possibly the best.

Ie, start by figuring out which are the airlines with both Amex MR and either Citi TYP or Chase UR transfers available, and figure out how many miles they typically need to the Asia destination(s) you're thinking about (many programs need more miles to some parts of Asia than other parts of Asia, so just specifying "Asia' is not specific enough to know the miles cost at most airlines).

Also familiarize yourself with the expiration policies of each airline you consider. The wikipost atop this thread:

Miles/Points that Do and Don't Expire

can be a good starting point for that.

It won't be until you have a list of airlines whose miles may work for you that you can know which programs you could use more points in for that trip, and it's only once you know which programs you could use more points in for that trip that people can give you suggestions for specific cards in those programs to apply for next.

Also, this is not only not necessarily the best time to be planning trips for soon, it's also not necessarily the best time to be applying for credit card from many banks. Many banks are temporarily cutting back on approvals and or temporarily tightening up restrictions on applying, during the downturn caused by the pandemic (because so many people are perhaps about to lose jobs as several-month-old anit-layoff measures start to end (if not extended soon by congress), and the banks can't tell if you're one of the people about to lose your job or not).

So you might well take a lot of time learning about all the the different airlines you might transfer to, while you're waiting for all of this to improve.