Seattle? I don't think so (SFO was planned) but realistically, LY is not going to be a great competitor in the US beyond their core market. I have no idea how BOS does, maybe OK w/biotech.
If you have to go beyond NYC, or LAX, (or are starting from there) its much easier to go on-line with UA, or DL than piece together an itin on multiple airlines. There are only so many places where you can fill 200+ seats a day in a 787, to get the other 50-75 you'd need to be profitable , you need to grab connections. UA can do this, LY is more challenged.
Don't get me wrong, I want to see LY be successful but it seems that its going to be exceptionally tough outside of NY especially in the US.