Perhaps someone could run flights akin to what CO is doing on the long thin routes such as EWR-OSL, EWR-EDI and others, with an internationally configured 757. Perhaps ATA should reconfigure a few of its 757-200s for its potential transatlantic low cost service...though if they have the range, based on existing operations a base at IND is probably more likely (even if less O&D).
I unfortunately don't see PIT supporting an O&D only route to Europe, particularly when connectins at EWR, ORD and IAD are easy. A few PIT-JFK flights on AA would significantly improve the competitive environment--AA is barely viable for transatlantic service from PIT currently. One must backtrack to either ORD or DFW (which is significantly longer for flights to Europe). UA at IAD and CO at EWR are the best options, with DL via CVG not bad for convenience (though frequency to London is poor).