I would fly, but be ready for stricter anti-viral measures than you may be used to.

The deaths in CA peaked a few weeks ago and are on the decline, whereas the deaths are still increasing in North Carolina.

In my lay opinion the flight will no be the risky part of your trip. The risks will come at the airport, rental car buses, rental cars, and Ubers.

Of course, your risk of injury or death is many times higher when driving across the country than in the air.