I usually end up doing several mileage runs per year and attempt to do them (as many of the above) to places I wouldn't typically go. Examples include Santiago Chile, Buenos Aires, etc.

In fact, doing a mileage run down south is MUCH better than Euro:
1: More miles (it seems most are 12-15K RT)
2: No jet-lag, you leave 5pm and arrive 8am next day - and it's 8am in the US still! Makes for an easy and fun weekend -w ithout your head being clouded - or fighting sleepiness.

The one problem seems to be the scarcity of deals to Brazil, Argentina - the two best locations.