In general, I do not have any trouble with motion sickness - however my stomach gets so upset on the Acela, I had to stop taking it - after leaving DC, if I'm using my laptop I have an upset stomach by the time we get to Baltimore. For my trips to NY I switched back to flying as I couldn't have all of the non-productive time on the Acela. For shorter trips I typically take the Regional now and do not have the motion sickness issue. I have talked to other business travelers who have told me they have the same motion sickness on the Acela.