Based purely and superificially on my personal comfort on the flights, I have to go for the A-330/340 but that is because I was in int'l business class (AC 340, US 330) on the ABs and domestic economy on the 777 (NH).
I found the 330 to be rather noisy in the cabin (ventilation). The 340 had no overhead storage compartments (a nuisance).
The NH 777 had a dreadful metallic grinding sound from the engines (PW).
As for number of engines, I crossed the Pacific 4x in a twin in the last 12 months, the Atlantic 6x.
[This message has been edited by terenz (edited 09-06-2000).]