OP is from Denver. An important difference is that MN tends to be fairly flat, so that one usually isn't driving up and down steep hills in snow and ice. This tends to make it easier.

Try to pick a rental car category that would be expected to be pretty good for winter driving and make sure to have a charged cell phone, warm clothing, water, etc. with you in the car. [Hint: You do not want a sports car no matter how fun and cute it looks.]

The mn511 website shows winter driving conditions, traffic conditions, road closures, accidents, etc. and should be checked before starting the drive.

I-90 gets heavy truck traffic and is rarely empty in a scary way, even at unusual hours, so it's not like a rural secondary road if the OP must drive late at night or in the early morning. However, I agree that the OP should try to drive only during daylight hours. Also, watch out for deer when driving in MN.