My wife and I were fling together on separate reservations last week, and I had called to get her an E+ seat next to me. No problem. When it looked probable that I would be upgraded, I went to the desk to see if I could move her seat to the aisle so that I could give her the F seat and have an aisle for myself. But while I waited, both of us were upgraded. It was a real surprise, as I didn't think that benefit would be available to her.
For what it's worth, the flight went out with several empty F seats.