I switch bags all the time based on what type and length of travel. My go to bag is a RedOxx Skytrain. Usually if I need to carry more I’ll use a RedOxx Mini Boss or a Tom Bihn Synapse 25 in addition to Sky Train.

Recently I did 8 days in Europe for business using the Skytrain for all clothing/toiletries. For office stuff a TravelOn satchel carrying a 12’’ MacBook, pens, notebook, cables, external battery and chargers