Based on assumptions and/or insider knowledge, what are some of the most and least profitable routes? Profitability, for this purpose can be in whichever way you wish to measure it... but hopefully something that reflects the calculations used by the airline and for business decisions.

This is probably a bit of a loaded question... I just often think about this myself and can't really come to a convincing answer other than gut instinct.

My guess: HKG-JFK/SFO/LAX/LHR are the most profitable.... something like BAH-DXB, not so much?