I would not recommend it. Real world numbers from Friday.

MAD JFK scheduled arrival 1415. This flight don’t have a good track record. Left MAD 30 min late and arrive JFK gate 47 min late at 1502. I was in first row of economy. Landslide with GE at 1516 with no checked bags.

Picked up rental car and drove by LGA around 1557. While NYC was final destination, my number show even if MAD JFK arrived on time, you need 15 minutes with GE to get to JFK curb followed by 45 minutes transit from JFK-LGA curb to curb (assuming no wait for taxi which I glanced and there were no wait for taxi), and arrive at LGA at least 60 minutes prior to departure assume you have PreCheck.

You need 2 hr minimum with GE and PreCheck assuming on time arrival to JFK, no checked luggage, no CBP secondary, no wait for taxi, have PreCheck (unknown until check-in as I recently got a SSSS 1st time in 10 years while being Trusted Traveler).