There's one Python based tool we use at work that will cause the entire Windows 10 GUI to freeze up for up to a minute or two at a time (dwm.exe uses 100% of one core during that time) if you use the tool for long enough. I'm not sure why that's the case, unfortunately.

As for everything else, Windows 10 works reasonably well for me--other than the updates happening at inconvenient times. Then again, my IT-administered Windows 7 laptop also eventually forces reboots for updates, so I'm kinda used to it.

(BTW, I should look into upgrading my 8.1 system at home. I finally stopped using WMC earlier this year and switched to MythTV after it trashed itself one too many times, thus eliminating my final reason for not upgrading.)