Yes, but. Drivers may choose to turn down long rides such as this and it is more than likely that most drivers do not want to take trip such as this as the return will almost certainly be a deadhead. Thus, even though EWR is full of Ubers, you may wait quite a while to find a willing driver.
A better alternative is one of the lower-end car services such as DIAL7. Generally more of a hassle and wait than an Uber, but not in this instance. All kinds of options for type of vehicle and that will determine price. You will also have a driver who will have GPS but is not 100% reliant on it as an EWR-area driver is likely to be in Great Neck.