A few years ago, my wallet containing my license was stolen the night before I was to leave for a trip to Las Vegas (I was flying in and renting a car there). As my wallet was stolen on a Friday night, there was nothing I could do about getting a replacement until Monday. I called up Hertz, and they told me there was absolutely no way I could rent a car without a license. I told them I still had my old, expired license, but that wouldn't cut it either.
Needless to say, I didn't do any driving on that trip!