Can't imagine doing 50 flights a year, let alone 100, 200!
My job gives me a lot of time off but being from Asia working on the US East Coast I spend most of it visiting family in Asia. I've probably done close to 20 round trips in economy between New York and Asia. I do at least 2 longhaul (Japan/Hong Kong) trips per year, and usually 2-3 domestic. This year, I finally started paying for J and I was so spoiled I don't think I can go back

.
So far/booked:
JFK <-> NRT in JL J (x2)
JFK <-> LIM in LATAM J
JFK <-> SAN in DL F
HND/NRT - HKG and back in JL J
HND/CTS/ITM JAL mileage run in Japan
Planning:
JFK <-> LHR in BA F (first time on BA, and first time in F)
LGA <-> DFW in DL F (to experience CSeries)
Aiming to hit JL Sapphire/JGC this year. I should probably be using AA for US domestic flights to get JAL miles but I think Delta is better.