There's a lot of business demand to/from PRG, it's not all tourists taking selfies in Wenceslas Square. However AA with a seasonal flight is not capturing much of that traffic.

There's quite a booming tech sector (which extents to Brno as well). The early morning PRG-LHR flight is almost exclusively connecting business pax, connecting to BA & AA. Once there were only three suitcases on the belt when I flew that route O&D.