If price is the same regardless is there any benefit in booking a multi city ticket over separate singles, particularly if there is a 2+ day gap between flights.

Eg,
Multi city ticket: AAA-BBB-CCC-DDD-AAA

Separate tickets: AAA-BBB, BBB-CCC, CCC-DDD, DDD-AAA

I have recently booked a multi city for a business trip but now have to tweak it and add a new leg. If it had been separate one-ways I could have just cancelled one entirely and taken the $150 loss. However, since its multi city, I'm faced with a $200 change fee + whatever the fare difference would be. Got me wondering if theres scenarios I should proactively be booking single tickets in the future.