Without question, a run will do it...a long slotary run, that gets you exausted. I remeber a series of Nike ads back around 1990 (they were full 2 page photos) where it would be a wids angle shot of either a barren landscape, a mountian, or a shot of a city. Each one had almost a runners mantra...something that made you feel even more lonely, but one with yourself, which made that feeling of isolation an asset, instead of a bad thing.
If I can find one of these ads, I'll post a link, but as they were 15 years ago, it'll be tough.