Originally Posted by poohhead80

Thank you for the info.

Here is more input from my side.
1. I will rent an automatic transmission vehicle - The last time I drove a manual shift was 20 years ago. I am willing to pay more for an automatic transmission vehicle.
2. I am planning to rent a mid or intermediate size vehicle. Based on my internet search, BMW 1 series vehicles are classified as a mid size vehicle. Rent price is around USD500 for a week including theft insurance and CDW. I am planning to take additional super coverage, as well.
3. I will rent a vehicle from one of the major rental car companies. I usually rent from Hertz, Avis, and Alamo/National in US.

My new tentative itinerary is
Day 1 Venice-Dolomites (170km)
Day 2 Dolomites
Day 3 Dolomites-Fussen (280km)
Day 4 Fussen
Day 5 Fussen-Interlaken (360km)
Day 6 Interlaken
Day 7 Interlaken-Milan (300km)
Day 8 Milan-Venice (280km)

I can see my itinerary still has a lot of driving.
My wife wants to include Interlaken and Fussne (non Italian tourist attractions) since we will have 4 days in Rome and 7 day mediterranean cruise before this road trip.
Thank you for your advice.