I don't run for redeemable miles, but I do run for status.
I probably spend a lot more than I should, especially now with business travel having taken a dump again (for me personally) but I do thoroughly enjoy the status privileges, and in some cases (baggage) also save a real amount of money.
And I try to make mileage runs on the routes I have interest in flying anyway. So I might upgrade my regular commute to J if it makes sense. Or I might go to a place I wasn't planning to go to, but where I was interested in going.