After many years with no false alarms I experienced 2 in the past 2 years. The first went off after I had just arrived from work in my 31st floor room at IC Bangkok. I wasted 30 seconds opening the safe to get my passport and laptop, then ran down 17 flights before learning that it was a false alarm. In the rush I forgot my room key, which cost me another 10 minutes waiting for a replacement. In retrospect maybe better to keep the safe unlocked when I'm in the room, those seconds may prove important. Though passport, phone and wallet are really the only 3 items I need to get home...

The 2nd incident was midday at the Grand Hyatt DC - this time only a 9 floor descent to street level, and again the false alarm was quickly cleared.

+1 I always request rooms far from the elevator, but now I think I may start requesting rooms near the stairs... and definitely will start memorizing the location.