I have not stayed in a suite but they upgraded me to the Deluxe King and it was definitely big enough.

Great treatment as Globalist too, and the breakfast is the best that I've had at a Hyatt in the US (and honestly just as good, or better than, the ones I've had in Asia). They are also very generous with a $100 credit per day (with 2 people, we never spent more than $50) and the credit is good up until noon (and there were no issues when, on one day, we got there just before noon and the check came well after noon) so you are eating on your schedule, not theirs (this is a BIG part of good service, to me -- service is about convenience). I don't feel that I should miss out on my free breakfast if I feel like sleeping in until 11 on my vacation -- this is one of the few hotels that agrees.

You are right in the middle of downtown. Very close to great bars and restaurants. You can walk almost everywhere, and take a cheap ($10-$15) lyft ride if you want to go somewhere outside of downtown. Of course not everyone likes this -- there is a reason that people live in the suburbs after all. Personally, I loved it. But then again I wouldn't want to live in a house with a yard and a white picket fence where you have to drive everywhere -- so it's a matter of personal preference.

There are a lot of VERY good breweries east of the highway. It's walking distance but the concierge suggested that we take a car due to the large number of homeless people living under the highway. I don't know how bad it really is, but we took her advice and took a lyft to get to the first brewery and then walked from brewery to brewery once we got there.

The hotel is an old, historic building. If you appreciate and enjoy that then it's a great place. If you want somewhere that looks like every other chain hotel in the US, that's what the Regency is for. There's nothing wrong with that, and I'll happily stay at a hotel like that, but I much prefer a place like the Driskill. Again, it's just about personal preference.