There is no one program that fit all or even fit you all the time.
I was focusing on my SPG in the past 3-4 years as they gave good benefit for Platinum member and they have reasonably hotel.
I was quite fed up with Accor especially after they change the program (and only the base point count toward elites) and also with APlus.
But with the recent change with Marriott, I may reconsider Accor. I really hope Accor put the hotels in order. If Accor manages to do that I will give most of the business back to Accor.