On United, I love the upper deck window seat because of the storage lockers right at your side. Usually in a lie-flat seat, I have to curl up to sleep because I'm always longer than the pod. But in these seats, I can sleep on my back with my feet on the storage locker. (It's far enough away from other seats that this doesn't disturb anyone else.)

The nose would be cool too - especially if you get a seat that has a somewhat forward-looking window. But that's usually F, and if I'm spending F miles I'm trying to get onto some airline not called United, and so far have never had a 747 nose seat. I flew LH F when that was upstairs.