You say "we" so I assume there are two of you. In that case, RJ may work for you. I flew AMM-JFK and was underwhelmed. The seats are cramped and if you're in a window seat, you have very little privacy and can't leave your seat without disturbing your neighbor. The soft product was also meh.
Iberia, OTOH, has excellent hard and soft products on their widebodies. So if you can have an IB codeshare for JFK-MAD, especially if it's the (brand new) A350, grab it. Then on MAD-TLV they often use widebodies, which as mentioned above are great, but even their 319s are OK (sort of like domestic F in the US).
Consider also the flight times. On TLV-JFK, RJ leaves around 8am whereas IB will require a much earlier start.

Shuly