Since you're using points or certs, that may guide your decision. The normal HGIs and Doubletrees are 70K, the upscale hotels like the Hiltons and Conrad are 80K, and the London is 95K. If you are on a budget, you can stay in Queens (Long Island City) around 50K, but things will be even further - but still just a subway ride away. Also, if your main focus is downtown, then stay downtown. If it's only one day of the three is downtown, then maybe midtown is better.