Well, if you're willing to drop serious cash on lie-flats for the plane ride, spending money on the room and F&B in Vegas at a high-end Strip casino is arguably a better deal in terms of $ spent vs. reward at making it "special". It's often not THAT hard to find a good comp deal during low season (MGM is sending me comp deals for $150 in F/B for 3 nights at Delano, and I am a flea, though a flea who used to use the Royal Offer combined with December/August stays in low season when it wasn't garbage like it is now, so they're not stupid), and frankly a meal at a Vegas high end restaurant is going to blow away any meal served at 35,000 feet that's been flash-frozen and reheated in a dinky airplane oven, and you'll spend a lot more time in that room on a 3-4 day stay than you will in a plane.
I'll add Wynn to the list of properties to consider.