DL seems to be retreating from SEA (cancellation of only flight to HKG). Given the proximity of SFO and LAX I don’t think they are missing much coverage there.
Agree that the southeast is the biggest hole but can’t think of and good place to put one. Florida is too far for anything but O&D traffic unless they develop Deep South America. But they have IAH and to a certain extent IAD for that.
Personally I’d rather see them develop LAX