If IC is a must, pick it based on location. Both are in Midtown, TS is lively and hectic 24/7. Barclay surroundings go quieter over the weekend as it is mainly a business area. I stay at Barclay if opting for an IC.
If IC isn't a must, then Indigo LES is in a great location if you want a younger crowd and happening area. Walking distance to all of lower Manhattan (LES, Soho, E+W Village, Chelsea and Down Town.
I must add though, Indigo is prone to a Tunnel & Bridge crowd.

Try Kimpton Ink48 if you can. Next on my list and a given without RA.