The entire purpose of Pre-Clearance is to avoid the necessity of clearance on arrival at a standard FIS. While, in very rare circumstances, CBP may choose to conduct a secondary inspection on arrival, when you arrive at your US POE, you will almost certainly be processed as any arriving domestic passenger and therefore, if connecting, will only need to pass through a TSA checkpoint if there is no airside physical route to your new departure gate. But, that would occur on a domestic connection as well.