Taking a slightly different view, when travelling with my husband, we try to get 5A and 5E, or 5F and 5K. Why? We are closer together and can chat across the aisle. It almost feels like a mini-suite. We're not too bothered by any traffic (the heaviest is usually just after boarding and take-off) or noise from the galley. As the crew know we are together, typically we get served things such as drinks, PJs, breakfast, etc. at the same time - this makes it feel more personalised.. We always buddy dine, with the E and F seats better as they have more room. This overall approach doesn't work so well in row 4, as 4E and 4F feel more restricted in space.