To a degree, I would say there is a disconnect between luxury and wilderness. In true wilderness areas, it is pretty hard to find true luxury accommodation. You usually have to compromise on one or the other.

I have stayed at quite a few of the properties listed by others above and will only add one favourite of mine that combines some aspects of luxury with wilderness.

https://arowhonpines.ca/

It is quite unique in many ways. No cell service, no phones or tv's in rooms, many would consider that alone as being wilderness. The 8 sided log cabin dining room with a large central stone fireplace and wrap around veranda is not your average dining room. Not seeing any wildlife would be an unusual day there. It is the only hotel actually in Algonquin Provincial Park and is reached from the highway over an 8 km(5 mile) gravel road. So yes, it really is in the middle of true wilderness.

Best time to visit: https://www.google.ca/search?q=algon...w=1366&bih=662