OK - I'll say it...I like chain hotels. I like consistency and knowing what I'm going to get. Sure, I like to explore a new city and try new food, but at the end of the day, there is something comforting about returning to something familiar. I once did a 2 week vacation throughout the UK staying mostly at "quaint" B&Bs. Some were nice, some were weird (carpet in the bathroom kind of weird), and a couple were dreadful (i.e. someone walking into the room in the middle of the night). I was very excited near the end to find a boring chain hotel with a normal shower, a good lock on the door and clean bedding. I've never stayed in a B&B again.
However, I don't let the points dictate. I collect points and have status in several programs and will use them for free nights when I can, but if there is a better hotel in a certain city, I'll pay for that and save my points for another time.