I liked the Novapark, which really is a block or two from downtown. Seems like it might have been transplanted from Switzerland and plopped into that location. I'll always stay either in Paris-Londres or surrounds or Barrio Lastarria, both of which have a lot more character than the gringo-oriented Sanhattan. OTOH I'm usually lower-budget and not burdened by unredeemed hotel-program points, and also have a bit of functional Spanish. The metro is also great for most transportation needs.