On trips that are part personal part work I'll often bring my work laptop (12" macbook) and my personal one (15" mbp). For a while I'd also need a work iPad so I'd have two laptops, two iPads, kindle, phone, spare phone, etc.
Only thing that's wrong with it is my back hurts carrying it and in non-TSA-pre airports it's a lot of stuff to take in and out of the bag.