I'm not sure why safety would come up as a question. Rome is one of the safest cities in the world. I can think of only a few cities in the USA that are as safe as Rome.

By the numbers, the only safer cities in the USA are NYC, Boston and San Diego. Out of the 161 major cities around the world cities in the USA are always among the most dangerous of any industrialized country. The risk of getting mugged, shot, or killed is much higher if you visit San Francisco, Las Vegas, Orlando, Philadelphia, Houston, Atlanta, St. Louis, Los Angeles, New Orleans, Baltimore, Washington DC, Memphis, etc, than if you visit Rome, or any other place in Italy.

Almost regardless of where you are from in the USA when you are in Italy you can relax, because now you are far less likely to be a victim of a crime than if you had stayed at home, unless you live in New York City, one of the few major cities that are safer than Rome. Of course, there are always petty crimes that people set themselves up for like getting pick pocketed, cell phone stolen, or purse snatched, which are almost completely preventable if you use the most basic precautions. See thread on pick pocketing.

The only area where crime is a nuisance is at the train station Termini, a few blocks from Boscolo Exedra.. There are pick pockets at the train station. If you are aware of it, then you won't get pick pocketed, Late at night people do get mugged around Termini, but it's unusual. That's about it.

Your real risk is staying at a terrible place like Boscolo Exedra. If you were going to a business convention then it would be a good place to stay because it has large conference rooms. Or, if you are going to Italy to just stay in the hotel and not go out it would be fine, because it's a nice hotel. But from a functional and esthetic perspective, you couldn't choose a worse location in all of central Rome than staying at the Boscolo Excedra. You will be staying on a huge traffic circle and bus stop with hundreds of buses and taxis parked in front, with horns honking, and emitting pollution. It has no sense of being in Rome. You might as well be in Chicago. Other than a small piece of the ancient wall, there is pretty much no feeling that you are even in Italy. When you go outside it is ugly, and to go anywhere you might want to go it is too far, and unless you are a really good walker, you will need a taxi.

It's safe, the hotel is nice, but the location is very bad for someone going as a tourist, unless it is a tourist who just wants to stay in the hotel and not go out. Most of the USA chain hotels are located a bit too far away from where things are happening. I'm a runner and strong walker, and I know Rome, so I could get from Boscolo to Piazza Navona without getting lost walking for half an hour, and I can get back the same way, cutting through the back streets. I suspect you are going to be needing taxis for everything if you stay out there. Unless you just like staying in the hotel, the only reason I can see for staying there is it's for one night, you're not going out, and you have an early train to catch, because it's just a few blocks from the train station, the only bad neighborhood in central Rome.