and here I am.
The location for Comiso airport is actually off-site, the lady from Avis was there at the airport to greet us and drive us to the off site location, which is in a hotel nearby.
She indeed mentioned they were closing the station, but that I could drop the keys at the reception when returning back, which I did, and someone from the Ragusa office would come and collect it.
Arrived there on the Saturday, dropped the keys and got a hotel shuttle ride to the airport.