Originally Posted by
skywardhunter
Basically at full load the plane might fly a bit skew if unbalanced is what I'm saying, keyword being "might"
It is no more of an issue than having more passengers seated on the left of an aircraft than on the right. On larger jets like widebodies, this is almost insignificant.
Modern load control programs are very good at calculating CoG and other parameters based on static LOPA and dynamic DCS inputs, including how these change as fuel burns off and how trim should be altered accordingly.