If the location is closed but they took the reservation anyway, in theory, they should try to accommodate you in some way, but in practice, this may be difficult. I suggest you contact Avis Customer Service at 800-352-7900 and see what they are willing to do for you.

Keep in mind that the Comiso/Ragusa may be a local franchise so options may be limited and/or they may just push back that there isn't anything they're willing to do. Worth a call though, and you certainly have a good case for some sort of compensation, but getting it may be another matter.